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Article

Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.

International journal of oncology - 1 Apr 2005

Komatsu Megumi, Kuroda Masahiro, Wang Yadi, St Clair Daret, Urano Muneyasu, Akaki Shiro, Asaumi Jun-Ichi, Kawasaki Shoji, Hiraki Yoshio, Kanazawa Susumu

Abstract excerpt

Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that converts cytotoxic superoxide radicals into hydrogen peroxide. MnSOD activity is lower in tumor cells, and MnSOD overexpression reportedly ameliorates malignant phenotypes. We established stable MnSOD overexpressing cell lines from a human osteosarcoma cell line, SaOS2, and then investigated the effects of MnSOD overexpression on plating...

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PMID: 15753978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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