Article
Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.
Oncogene - 18 May 1995
Li J J, Oberley L W, St Clair D K, Ridnour L A, Oberley T D
Abstract excerpt
Human manganese containing superoxide dismutase (MnSOD) cDNA was transfected into a human breast cancer cell line (MCF-7) in order to examine the effect of increased functional MnSOD on the cellular phenotype. A MnSOD-overexpressing clone was compared to control vector-transfected cells and to wild type MCF-7 cells. Southern blotting indicated incorporation of MnSOD cDNA into genomic DNA in the MnSOD...
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