Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

21 Feb 2013

Abstract excerpt

Normal cells require adhesion to extracellular matrix for survival. Cell detachment causes a drastic increase in reactive oxygen species (ROS) that promotes anoikis. In the present study, we observed that upon detachment from matrix, human mammary epithelial cells strongly upregulate manganese superoxide dismutase (MnSOD, or SOD2), a principal mitochondrial antioxidant enzyme that detoxifies ROS through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Effects of Radiation Exposure
Share to Glutathione Transferases and Polymorphisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23429290
DOI: 10.1038/cddis.2013.20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manganese superoxide dismutase promotes anoikis resistance and tumor metastasisPMID 23429290Read ↗

Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.Semantic proximity Read ↗

High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin.Semantic proximity Read ↗

Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma.Semantic proximity Read ↗

Targeting extracellular ROS signaling of tumor cells.Semantic proximity Read ↗

MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.Semantic proximity Read ↗

Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.Semantic proximity Read ↗

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.Semantic proximity Read ↗

Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase.Semantic proximity Read ↗

Induction of apoptosis by adenovirus-mediated manganese superoxide dismutase overexpression in SV-40-transformed human fibroblasts.Semantic proximity Read ↗

Alteration of cellular phenotype and responses to oxidative stress by manganese superoxide dismutase and a superoxide dismutase mimic in RWPE-2 human prostate adenocarcinoma cells.Semantic proximity Read ↗

Anoikis and metastatic potential of cloudman S91 melanoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.