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Article

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.

British journal of pharmacology - 1 May 2005

Lefranc-Jullien Solveig, Lisowski Vincent, Hernandez Jean-François, Martinez Jean, Checler Frédéric

Abstract excerpt

1 The beta-secretase BACE1 is one of the enzymes that contribute to the production of the Abeta peptide, in vitro and in vivo. JMV1195 was previously shown to inhibit BACE activity in vitro but was unable to block cellular BACE activity. We have designed a new permeable inhibitor, JMV2764 that corresponds to a derivative of JMV1195 to which a penetratin sequence had been added at its N-terminus. We have assessed...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 15753947
DOI: 10.1038/sj.bjp.0706183
PMCID: PMC1576132

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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