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Article

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Jun 2013

Eketjäll Susanna, Janson Juliette, Jeppsson Fredrik, Svanhagen Alexander, Kolmodin Karin, Gustavsson Susanne, Radesäter Ann-Cathrin, Eliason Kristina, Briem Sveinn, Appelkvist Paulina, Niva Camilla, Berg Anna-Lena, Karlström Sofia, Swahn Britt-Marie, Fälting Johanna

Abstract excerpt

Aβ, the product of APP (amyloid precursor protein), has been implicated in the pathophysiology of Alzheimer's disease (AD). β-Site APP cleaving enzyme1 (BACE1) is the enzyme initiating the processing of the APP to Aβ peptides. Small molecule BACE1 inhibitors are expected to decrease Aβ-peptide generation and thereby reduce amyloid plaque formation in the brain, a neuropathological hallmark of AD. BACE1 inhibition...

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Source

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Identifiers

PMID: 23761903
DOI: 10.1523/JNEUROSCI.1165-13.2013
PMCID: PMC6618391

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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