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Article

Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1

6 Jan 2011

Abstract excerpt

β-Secretase (BACE1) is an attractive drug target for Alzheimer disease. However, the design of clinical useful inhibitors targeting its active site has been extremely challenging. To identify alternative drug targeting sites we have generated a panel of BACE1 monoclonal antibodies (mAbs) that interfere with BACE1 activity in various assays and determined their binding epitopes. mAb 1A11 inhibited BACE1 in vitro...

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PMID: 21209097
DOI: 10.1074/jbc.m110.194860

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