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Article

The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.

Current biology : CB - 8 Mar 2005

Kawakami Atsushi, Nojima Yasuhiro, Toyoda Atsushi, Takahoko Mikako, Satoh Miki, Tanaka Hideomi, Wada Hironori, Masai Ichiro, Terasaki Harumi, Sakaki Yoshiyuki, Takeda Hiroyuki, Okamoto Hitoshi

Abstract excerpt

The Hedgehog (Hh) signal plays a pivotal role in induction of ventral neuronal and muscle cell types around the midline during vertebrate development [1]. We report that the gene disrupted in zebrafish you mutants, in which Hh signaling is impaired, encodes the secreted matrix protein Scube2. Con...

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Identifiers

PMID: 15753045
DOI: 10.1016/j.cub.2005.02.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15753045-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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