Article
MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2002
Nishioka Michiho, Kohno Takashi, Tani Masachika, Yanaihara Nozomu, Tomizawa Yoshio, Otsuka Ayaka, Sasaki Shigeru, Kobayashi Keiko, Niki Toshiro, Maeshima Arafumi, Sekido Yoshitaka, Minna John D, Sone Saburo, Yokota Jun
Abstract excerpt
Loss of heterozygosity on chromosome 22q has been detected in approximately 60% of advanced nonsmall cell lung carcinoma (NSCLC) as well as small cell lung carcinoma (SCLC), suggesting the presence of a tumor suppressor gene on 22q that is involved in lung cancer progression. Here, we isolated a myosin family gene, MYO18B, located at chromosome 22q12.1 and found that it is frequently deleted, mutated, and...
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