Article
Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse.
Genes, chromosomes & cancer - 1 Jul 2012
Perotti Daniela, Spreafico Filippo, Torri Federica, Gamba Beatrice, D'Adamo Pio, Pizzamiglio Sara, Terenziani Monica, Catania Serena, Collini Paola, Nantron Marilina, Pession Andrea, Bianchi Maurizio, Indolfi Paolo, D'Angelo Paolo, Fossati-Bellani Franca, Verderio Paolo, Macciardi Fabio, Radice Paolo
Abstract excerpt
Despite the excellent survival rate of Wilms tumor (WT) patients, only approximately one-half of children who suffer tumor recurrence reach second durable remission. This underlines the need for novel markers to optimize initial treatment. We investigated 77 tumors using Illumina 370CNV-QUAD genotyping BeadChip arrays and compared their genomic profiles to detect copy number (CN) abnormalities and allelic ratio...
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