Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1

1 Feb 2019

Abstract excerpt

The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclear. Here we demonstrate that the knockdown of HERC4 in human breast cancer cells dramatically suppressed their proliferation, survival, migration, and tumor growth in vivo, while the overexpression of HERC4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30710319
DOI: 10.1007/s13238-019-0607-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1PMID 30710319Read ↗

WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer CellsSemantic proximity Read ↗

Unraveling the Potential Role of NEDD4-like E3 Ligases in CancerSemantic proximity Read ↗

HERC1 regulates breast cancer cells migration and invasionSemantic proximity Read ↗

Cullin-RING Ligase 4 in Cancer: Structure, Functions, and MechanismsSemantic proximity Read ↗

Novel RING E3 Ubiquitin Ligases in Breast CancerSemantic proximity Read ↗

E3 Ubiquitin Ligases as Cancer Targets and BiomarkersSemantic proximity Read ↗

Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancersSemantic proximity Read ↗

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectivesSemantic proximity Read ↗

Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast CancerSemantic proximity Read ↗

LATS tumor suppressor: A new governor of cellular homeostasisSemantic proximity Read ↗

The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implicationsSemantic proximity Read ↗

A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.