Article
Mutations of the epidermal growth factor receptor gene in gastrointestinal tract tumor cell lines.
Oncology reports - 1 May 2006
Kimura Toshimoto, Maesawa Chihaya, Ikeda Kenichiro, Wakabayashi Go, Masuda Tomoyuki
Abstract excerpt
The epidermal growth factor receptor (EGFR) is commonly overexpressed in many human tumors including gastrointestinal tract tumors. Gefitinib is a selective inhibitor of EGFR tyrosine kinase, and blocks several signal transduction pathways including those involved in tumor cell proliferation, angiogenesis and metastasis. Recent mutational and biological studies have suggested that mutations in the tyrosine kinase...
Topics
- Adenocarcinoma
- Cell Line, Tumor
- DNA Mutational Analysis
- Gastrointestinal Neoplasms
- Genes, erbB-1
- Humans
- Japan
- Mutation, Missense
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- RNA, Messenger