Article
Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2006
Kwak Eunice L, Jankowski Janusz, Thayer Sarah P, Lauwers Gregory Y, Brannigan Brian W, Harris Patricia L, Okimoto Ross A, Haserlat Sara M, Driscoll David R, Ferry David, Muir Beth, Settleman Jeff, Fuchs Charles S, Kulke Matthew H, Ryan David P, Clark Jeff W, Sgroi Dennis C, Haber Daniel A, Bell Daphne W
Abstract excerpt
PURPOSE: Specific activating mutations within the epidermal growth factor receptor (EGFR) identify a subset of non-small cell lung cancers with dramatic sensitivity to the specific tyrosine kinase inhibitors (TKI), gefitinib and erlotinib. Despite the abundant expression of EGFR protein in a broad range of epithelial cancers, EGFR mutations have not been reported in a substantial fraction of other cancers. Given...
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