Somatic Mutations of<i>EGFR</i>in Colorectal Cancers and Glioblastomas

Abstract excerpt

To the Editor: Recent reports suggest that mutations in the epidermal growth factor receptor (EGFR) gene predict sensitivity to EGFR kinase inhibitors. In particular, patients with lung cancers containing mutations in the EGFR kinase domain have had responses to gefitinib.1,2 Are similar EGFR mutations present in a significant fraction of other tumor types for which gefitinib might be suitable therapy? To answer...

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