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Article

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex.

Nucleic acids research - 1 Jan 2005

Banerjee Sreeparna, Flores-Rozas Hernan

Abstract excerpt

Cadmium (Cd2+) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway. In this study, we have tested the effect of Cd2+ exposure on the enzymatic activity of the mismatch binding complex MSH2-MSH6. Our results indicate that Cd2+ is highly inhibitory to the ATP binding and hydrolysis activities of MSH2-MSH6, and less inhibitory to its DNA mismatch binding activity. The inhibition of the...

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Source

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Identifiers

PMID: 15746000
DOI: 10.1093/nar/gki291
PMCID: PMC552968

Genes

MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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