Article
Coamplification of hprt cDNA and gamma T-cell receptor sequences from 6-thioguanine resistant human T-lymphocytes.
Mutation research - 1 Aug 1993
Curry J, Skandalis A, Holcroft J, de Boer J, Glickman B
Abstract excerpt
The nature of mutation at the HPRT locus in human T-lymphocytes in vivo is currently a subject of considerable interest. Determination of clonality in individual mutant T-lymphocytes is essential for the proper interpretation. This requires the molecular analysis of their respective T-cell recept...
Topics
- Adult
- Base Sequence
- Cells, Cultured
- DNA
- Drug Resistance
- Female
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocytes
- Thioguanine