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Article

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.

PloS one - 1 Jan 2012

Perdomo José, Jiang Xing-Mai, Carter Daniel R, Khachigian Levon M, Chong Beng H

Abstract excerpt

Friend of GATA 2 (FOG-2), a co-factor of several GATA transcription factors (GATA-4, -5 and 6), is a critical regulator of coronary vessel formation and heart morphogenesis. Here we demonstrate that FOG-2 is SUMOylated and that this modification modulates its transcriptional activity. FOG-2 SUMOylation occurs at four lysine residues (K324, 471, 915, 955) [corrected]. Three of these residues are part of the...

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Identifiers

PMID: 23226341
DOI: 10.1371/journal.pone.0050637
PMCID: PMC3511347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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