SUMO--a post-translational modification with therapeutic potential?

Abstract excerpt

Sumoylation is a covalent modification, which is mediated by small ubiquitin-like modifier (SUMO) polypeptides. A growing body of evidence has shown that sumoylation affects the functional properties of many substrates in the regulation of cellular processes. Recent reports indicate the crucial role of sumoylation in human diseases including familial dilated cardiomyopathy, suggesting that targeting of...

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• Cardiovascular Diseases
• Cardiovascular System
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• Drug Delivery Systems
• Models, Biological