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Article

Three new familial hemiplegic migraine mutants affect P/Q-type Ca(2+) channel kinetics.

The Journal of biological chemistry - 31 Mar 2000

Kraus R L, Sinnegger M J, Koschak A, Glossmann H, Stenirri S, Carrera P, Striessnig J

Abstract excerpt

Missense mutations in the pore-forming human alpha(1A) subunit of neuronal P/Q-type Ca(2+) channels are associated with familial hemiplegic migraine. We studied the functional consequences on P/Q-type Ca(2+) channel function of three recently identified mutations, R583Q, D715E, and V1457L after i...

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Source

Identifiers

PMID: 10734061
DOI: 10.1074/jbc.275.13.9239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10734061-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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