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Article

The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2005

Hayakawa Makio, Kitagawa Hideo, Miyazawa Keiji, Kitagawa Masatoshi, Kikugawa Kiyomi

Abstract excerpt

FWD1/beta-TrCP is the F-box protein that functions as the receptor subunit of the SCF(FWD1/beta-TrCP) ubiquitin ligase and has been shown to be responsible for the degradation of important signaling molecules such as IkappaBs and beta-catenin. Protein substrates of FWD1/beta-TrCP contain a consensus DSGPsiXS motif (where Psi represents a hydrophobic residue and X represents any amino acid). Recognition by...

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Identifiers

PMID: 15743413
DOI: 10.1111/j.1365-2443.2005.00834.x

Genes

FGD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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