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Article

Structural basis of selective ubiquitination of TRF1 by SCFFbx4.

Developmental cell - 16 Feb 2010

Zeng Zhixiong, Wang Wei, Yang Yuting, Chen Yong, Yang Xiaomei, Diehl J Alan, Liu Xuedong, Lei Ming

Abstract excerpt

TRF1 is a critical regulator of telomere length. As such, TRF1 levels are regulated by ubiquitin-dependent proteolysis via an SCF E3 ligase where Fbx4 contributes to substrate specification. Here, we report the crystal structure of the Fbx4-TRF1 complex at 2.4 A resolution. Fbx4 contains an unusu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20159592
DOI: 10.1016/j.devcel.2010.01.007
PMCID: PMC6097615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159592-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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