Article
A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate.
Physiological genomics - 11 May 2005
Dutil Julie, Eliopoulos Vasiliki, Marchand Eve-Lyne, Devlin Alison M, Tremblay Johanne, Prithiviraj Kalyani, Hamet Pavel, Migneault Annik, deBlois Denis, Deng Alan Y
Abstract excerpt
Vascular hyperplasia may be involved in the remodeling of vasculature. It was unknown whether there were genetic determinants for aortic smooth muscle cell number (SMCN) and, if so, whether they acted independently of those for blood pressure (BP). To unravel this issue, we utilized congenic strains previously constructed for BP studies. These strains were made by replacing various chromosome 2 segments of the...
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