Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.

doi:10.1158/0008-5472.CAN-04-3263

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Article

Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.

Cancer research - 15 Feb 2005

Schaper Inke Diana, Marcuzzi Gian Paolo, Weissenborn Sönke Jan, Kasper Hans Udo, Dries Volker, Smyth Neil, Fuchs Pawel, Pfister Herbert

Abstract excerpt

The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer development in epidermodysplasia verruciformis patients and its early genes E2, E6, and E7 have been implicated in cell transformation in vitro. To examine the functions of these genes in vivo we integrated the complete early region of HPV8 into the genome of DBA/Bl6 mice. To target their expression to the basal layer of the squamous...

Topics

Animals
Genes, Viral
Genes, p53
Keratin-14
Keratins
Mice
Mice, Inbred DBA
Mice, Transgenic
Mutation
Papillomaviridae
Promoter Regions, Genetic
Skin Neoplasms
Transcription, Genetic

Source

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Identifiers

PMID: 15735026
DOI: 10.1158/0008-5472.CAN-04-3263

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