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Article

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.

15 Jun 1993

Abstract excerpt

Certain "high-risk" anogenital human papillomaviruses (HPVs) have been associated with the majority of human cervical carcinomas. In these cancers, two papillomaviral genes, E6 and E7, are commonly expressed. In this study we provide evidence that expression of the E6 and E7 genes from the high-risk HPV-16 in the skin of transgenic mice potentiated the development of preneoplastic lesions, and a high percentage...

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Identifiers

PMID: 8390671
DOI: 10.1073/pnas.90.12.5583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.PMID 8390671Read ↗

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogeneSemantic proximity Read ↗

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo.Semantic proximity Read ↗

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiationSemantic proximity Read ↗

Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis.Semantic proximity Read ↗

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.Semantic proximity Read ↗

Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic miceSemantic proximity Read ↗

Abnormalities of epidermal differentiation associated with expression of the human papillomavirus type 1 early region in transgenic mice.Semantic proximity Read ↗

Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and woundingSemantic proximity Read ↗

Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.Semantic proximity Read ↗

Skin Hyperproliferation and Susceptibility to Chemical Carcinogenesis in Transgenic Mice Expressing E6 and E7 of Human Papillomavirus Type 38Semantic proximity Read ↗

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.Semantic proximity Read ↗

Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease.Semantic proximity Read ↗

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