Article
Fast track selection of immunogens for novel vaccines through visualisation of the early onset of the B-cell response.
Vaccine - 14 Mar 2005
Scibelli Antonio, van der Most Robbert G, Turkstra Johan A, Ariaans Mark P, Arkesteijn Ger, Hensen Evert J, Meloen Rob H
Abstract excerpt
A most essential step in vaccine research and development, ie vaccine studies in animals, seriously suffer from long timespans needed to arrive at effective immunogens. In this report we show how almost immediately after vaccination the antibody inducing potential of low immunogenic 'self' antigens can be accurately assessed. (We expect that this timespan can be reduced even more when 'non self' antigens are...
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