Article
Use of cell-tracking dyes to determine proliferation precursor frequencies of antigen-specific T cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004
Givan Alice L, Fisher Jan L, Waugh Mary G, Bercovici Nadège, Wallace Paul K
Abstract excerpt
The T-cell receptor provides T cells with specificity for antigens of particular molecular structure (the "epitope"); the T-cell pool in an individual responds to the presence of many different antigenic epitopes, but any particular T cell will respond preferentially to one defined epitope. After stimulation of a T cell by the binding of its receptor to its cognate antigen in the context of a major...
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