Do developing B cells need antigen?

Abstract excerpt

Just as potentially useful T cells are positively selected by MHC-peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations with the capacity to recognize polysaccharide or protein structures on pathogens. Recent studies indicate that the repertoire of B cells entering the periphery is not shaped by specific stimuli, but that mature B cell...

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