Article
Enzymatic detection of precursor cell populations of preneoplastic foci positive for gamma-glutamyltranspeptidase in rat liver.
International journal of cancer - 10 Jul 2005
Satoh Kimihiko, Takahashi Gen, Miura Tomisato, Hayakari Makoto, Hatayama Ichiro
Abstract excerpt
An improved staining method for gamma-glutamyltranspeptidase (GGT) was developed using Vibratome-prepared microslices. Microscopic precursor cell populations of preneoplastic foci positive for the marker enzyme were detectable sequentially in rat liver by tracing back from 5 to 1 week after carcinogen injection in a hepatocarcinogenesis model. Mirror-image comparisons of serial sections stained for GGT activity...
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