Article
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.
Biomedica biochimica acta - 1 Jan 1991
Ciechanover A, Gropper R, Schwartz A L
Abstract excerpt
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at the restrictive temperature (Ciechanover, A., Finley, D., and Varshavsky, A. (1984) Cell 37, 57-66). It is not known whether the ubiquitin system is also involved in the...
Topics
- Adenine
- Amino Acid Sequence
- Animals
- Cell Line
- Cycloheximide
- Ligases
- Lysosomes
- Molecular Sequence Data
- Mutation
- Proteins
- Stress, Physiological
- Temperature
- Ubiquitin-Activating Enzymes
- Ubiquitin-Protein Ligases