Article
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.
Biomedica biochimica acta - 1 Jan 1991
Ciechanover A, Gropper R, Schwartz A L
Abstract excerpt
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at the restrictive temperature (Ciechanover, A., Finley, D., and Varshavsky, A. (1984) Cell 37, 57-66). It is not known whether the ubiquitin system is also involved in the degradation of long-lived proteins. In the present study we show that upon shifting the mutant cells to the restrictive...
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