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Article

Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005

Kaiser Brett K, Barahmand-Pour Fariba, Paulsene Wendy, Medley Scott, Geraghty Daniel E, Strong Roland K

Abstract excerpt

The NKG2x/CD94 family of C-type lectin-like immunoreceptors (x = A, B, C, E, and H) mediates surveillance of MHC class Ia cell surface expression, often dysregulated during infection or tumorigenesis, by recognizing the MHC class Ib protein HLA-E that specifically presents peptides derived from class Ia leader sequences. In this study, we determine the affinities and interaction thermodynamics between three...

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Share to Antigen Presentation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

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Source

Identifiers

PMID: 15728498
DOI: 10.4049/jimmunol.174.5.2878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics.PMID 15728498Read ↗

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