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Article

Poly(ADP-ribosylation) and genomic stability

1 Jun 2005

Abstract excerpt

Poly(ADP-ribose) polymerases (PARPs) catalyze the synthesis of ADP-ribose polymers and attach them to specific target proteins. To date, 6 members of this protein family in humans have been characterized. The best-known PARP, PARP-1, is located within the nucleus and has a major function in DNA repair but also in the execution of cell death pathways. Other PARP enzymes appear to carry out highly specific...

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PMID: 15959554
DOI: 10.1139/o05-039

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