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Article

Protein evolution in viral quasispecies under selective pressure: a thermodynamic and phylogenetic analysis.

Gene - 14 Mar 2005

Briones Carlos, Bastolla Ugo

Abstract excerpt

The evolution of RNA viruses under antiviral pressure is characterized by high mutation rates and strong selective forces that induce extremely rapid changes of protein sequences. This makes the course of molecular evolution directly observable on time scales of months. Here we study the interplay between selection for drug resistance and selection for thermodynamic stability in the protease (PR) and the reverse...

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Source

Identifiers

PMID: 15725390
DOI: 10.1016/j.gene.2004.12.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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