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Article

Molecular dynamics studies on HIV-1 protease drug resistance and folding pathways.

Proteins - 1 Jun 2001

Cecconi F, Micheletti C, Carloni P, Maritan A

Abstract excerpt

Drug resistance to HIV-1 protease involves the accumulation of multiple mutations in the protein. We investigate the role of these mutations by using molecular dynamics simulations that exploit the influence of the native-state topology in the folding process. Our calculations show that sites con...

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PMID: 11340653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11340653-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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