Article
GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients.
Biochemical and biophysical research communications - 1 Apr 2005
Sasaki Masahiro, Karube Akihiro, Karube Yuko, Watari Michiko, Sakuragi Noriaki, Fujimoto Seiichiro, Dahiya Rajvir
Abstract excerpt
Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG repeat are inversely and linearly related to AR activity and associated with endometrial cancer....
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