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The expansion of the CAG repeat in exon 1 of the human androgen receptor gene is associated with uterine endometrial carcinoma.

Molecular carcinogenesis - 1 Mar 2000

Sasaki M, Dahiya R, Fujimoto S, Ishikawa M, Oshimura M

Abstract excerpt

Uterine endometrial carcinoma is common among women. Several reports indicated that this cancer is influenced by androgens mediated through their receptors. The human androgen receptor gene contains a polymorphic CAG repeat in the coding region of exon 1. Other studies suggested a possible association between the CAG repeat of this gene and the development of several cancers. DNA samples isolated from 29 patients...

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PMID: 10708486

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