Article
Alleles with short CAG and GGN repeats in the androgen receptor gene are associated with benign endometrial cancer.
International journal of cancer - 15 Mar 2006
Rodríguez Germán, Bilbao Cristina, Ramírez Raquel, Falcón Orlando, León Laureano, Chirino Ricardo, Falcón Orlando, Díaz B Pilar, Rivero Juan F, Perucho Manuel, Díaz-Chico B Nicolás, Díaz-Chico Juan C
Abstract excerpt
The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects the amount of the AR protein transcribed. The endometrium contains ARs and the androgens have antiproliferative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
