Article
Androgen receptor polymorphisms and endometrial cancer risk.
International journal of cancer - 1 Mar 2006
McGrath Monica, Lee I-Min, Hankinson Susan E, Kraft Peter, Hunter David J, Buring Julie, De Vivo Immaculata
Abstract excerpt
The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inversely correlated with the transcriptional activity of this gene. We assessed the association...
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