Article
A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant.
Brain research. Developmental brain research - 21 Feb 1992
Helekar S A, Noebels J L
Abstract excerpt
Hippocampal CA3 pyramidal neurons in the adult epileptic mutant mouse tottering (tg) show normal intrinsic membrane properties, yet fire abnormally prolonged paroxysmal depolarizing shifts (PDS) during in vitro exposure to elevated extracellular potassium solutions. Intracellular recordings in im...
Topics
- Aging
- Animals
- Electroencephalography
- Electrophysiology
- Hippocampus
- In Vitro Techniques
- Membrane Potentials
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Phenotype
- Potassium
- Pyramidal Tracts
- Seizures