Article
Distinct behavioral phenotypes in novel "fast" kindling-susceptible and "slow" kindling-resistant rat strains selected by stimulation of the hippocampal perforant path.
Neurobiology of disease - 1 Jan 2016
Langberg Tomer, Dashek Ryan, Mulvey Bernard, Miller Kimberly A, Osting Susan, Stafstrom Carl E, Sutula Thomas P
Abstract excerpt
Kindling is a phenomenon of activity-dependent neural circuit plasticity induced by repeated seizures that results in progressive permanent increases in susceptibility to epilepsy. As the permanent structural and functional modifications induced by kindling include a diverse range of molecular, cellular, and functional alterations in neural circuits, it is of interest to determine if genetic background associated...
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