Article
NOD1 variation, immunoglobulin E and asthma.
Human molecular genetics - 1 Apr 2005
Hysi Pirro, Kabesch Michael, Moffatt Miriam F, Schedel Michaela, Carr David, Zhang Youming, Boardman Brenda, von Mutius Erika, Weiland Stephan K, Leupold Wolfgang, Fritzsch Christian, Klopp Norman, Musk A William, James Alan, Nunez Gabriel, Inohara Naohiro, Cookson William O C
Abstract excerpt
Asthma is a familial inflammatory disease of the airways of the lung. Microbial exposures in childhood protect against asthma through unknown mechanisms. The innate immune system is able to identify microbial components through a variety of pattern-recognition receptors (PRRs). NOD1 is an intracellular PRR that initiates inflammation in response to bacterial diaminopimelic acid (iE-DAP). The NOD1 gene is on...
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