Article
Association of NOD1 polymorphisms with atopic eczema and related phenotypes.
The Journal of allergy and clinical immunology - 1 Jul 2005
Weidinger Stephan, Klopp Norman, Rummler Lars, Wagenpfeil Stefan, Novak Natalija, Baurecht Hans-Joerg, Groer Werner, Darsow Ulf, Heinrich Joachim, Gauger Anke, Schafer Torsten, Jakob Thilo, Behrendt Heidrun, Wichmann Hans-Erich, Ring Johannes, Illig Thomas
Abstract excerpt
BACKGROUND: Interactions with microbial pathogens are crucial for the maturation of the immune system. The nucleotide-binding oligomerization domain protein 1 (NOD1) is a cytosolic receptor sensing a muropeptide found mostly in gram-negative bacterial peptidoglycans. NOD1 is located on chromosome 7p14-p15, a region that has been linked with atopy. Recently, polymorphisms of the closely related NOD2 have been...
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