Article
The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells.
Respiratory research - 20 Jan 2005
Syed Farhat, Panettieri Reynold A, Tliba Omar, Huang Chris, Li Katherine, Bracht Michelle, Amegadzie Bernard, Griswold Don, Li Li, Amrani Yassine
Abstract excerpt
BACKGROUND: Growing evidence shows that interleukin 13 (IL-13) may play an essential role in the development of airway inflammation and bronchial hyper-responsiveness (BHR), two defining features of asthma. Although the underlying mechanisms remain unknown, a number of reports have shown that IL-13 may exert its deleterious effects in asthma by directly acting on airway resident cells, including epithelial cells...
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