Article
A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children.
The Journal of allergy and clinical immunology - 1 Mar 2000
Graves P E, Kabesch M, Halonen M, Holberg C J, Baldini M, Fritzsch C, Weiland S K, Erickson R P, von Mutius E, Martinez F D
Abstract excerpt
BACKGROUND: Increased levels of total serum IgE are a strong risk factor for the development of asthma. IgE is also involved in host defenses against parasites and fungi. Linkage of total serum IgE with markers located close to the 3 Mb cluster of cytokine genes in chromosome 5q31 has been reported. IL-4 or IL-13 are regarded as essential for IgE synthesis. OBJECTIVE: We tested whether polymorphisms in the IL-13...
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