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Article

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Drosten Matthias, Sum Eleanor Y M, Lechuga Carmen G, Simón-Carrasco Lucía, Jacob Harrys K C, García-Medina Raquel, Huang Sidong, Beijersbergen Roderick L, Bernards Rene, Barbacid Mariano

Abstract excerpt

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell proliferation. However, little is known regarding the molecular events that connect Ras signaling with the cell cycle. Here, we...

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Identifiers

PMID: 25288756
DOI: 10.1073/pnas.1417549111
PMCID: PMC4210339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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