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Article

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

The EMBO journal - 1 Jun 1999

Sanz L, Sanchez P, Lallena M J, Diaz-Meco M T, Moscat J

Abstract excerpt

The two members of the atypical protein kinase C (aPKC) subfamily of isozymes (zetaPKC and lambda/iotaPKC) are involved in the control of nuclear factor kappaB (NF-kappaB) through IKKbeta activation. Here we show that the previously described aPKC-binding protein, p62, selectively interacts with RIP but not with TRAF2 in vitro and in vivo. p62 bridges the aPKCs to RIP, whereas the aPKCs link IKKbeta to p62. In...

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Topics

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Share to I-kappa B Kinase
Share to I-kappa B Proteins
Share to Receptor-Interacting Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Tumor Necrosis Factor, Type I

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Share to TNF Receptor-Associated Factor 1

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Source

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Identifiers

PMID: 10356400
DOI: 10.1093/emboj/18.11.3044
PMCID: PMC1171386

Genes

TNF
TRADD
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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