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Article

Increased levels of the HER1 adaptor protein Ruk l /CIN85 contribute to breast cancer malignancy

12 Jul 2012

Abstract excerpt

The adaptor protein regulator for ubiquitous kinase/c-Cbl-interacting protein of 85kDa (Ruk/CIN85) was found to modulate HER1/EGFR signaling and processes like cell adhesion and apoptosis. Although these features imply a role in carcinogenesis, it is so far unknown how and by which molecular mechanisms Ruk/CIN85 could affect a certain tumor phenotype. By analyzing samples from breast cancer patients, we found...

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PMID: 22791810
DOI: 10.1093/carcin/bgs228

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Related research

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Increased levels of the HER1 adaptor protein Ruk l /CIN85 contribute to breast cancer malignancyPMID 22791810Read ↗

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Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85alpha regulatory subunit of PI 3-kinase.Semantic proximity Read ↗

[Ubiquitination-mediated degradation of epidermal growth factor receptor].Semantic proximity Read ↗

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SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion.Semantic proximity Read ↗

CrkIII: a novel and biologically distinct member of the Crk family of adaptor proteinsSemantic proximity Read ↗

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