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Article

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.

The Journal of biological chemistry - 22 Apr 2005

Sun Yaping, Leaman Douglas W

Abstract excerpt

Double-stranded RNA (dsRNA) accumulates in virally infected cells, leading to induction of genes encoding proteins involved in signaling, apoptosis, protein synthesis/processing, and cell metabolism. Noxa is a BH3-containing mitochondrial protein that contributes to apoptosis by disrupting mitochondrial outer membrane integrity. Here we demonstrate potent induction of Noxa expression by exposure of cells to...

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Identifiers

PMID: 15705586
DOI: 10.1074/jbc.M412630200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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