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Article

MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

7 Mar 2009

Abstract excerpt

BACKGROUND: Host responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1 interferons (IFN-I), however its role in virus-induced apoptotic responses has not been elucidated. PRINCIPAL FINDINGS: We show that MAVS causes apoptosis independent...

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PMID: 19404494
DOI: 10.1371/journal.pone.0005466

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