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Article

The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1.

Journal of virology - 1 Oct 2009

Mohd-Ismail Nur Khairiah, Deng Lin, Sukumaran Sunil Kumar, Yu Victor C, Hotta Hak, Tan Yee-Joo

Abstract excerpt

The hepatitis C virus (HCV) core protein is known to modulate apoptosis and contribute to viral replication and pathogenesis. In this study, we have identified a Bcl-2 homology 3 (BH3) domain in the core protein that is essential for its proapoptotic property. Coimmunoprecipitation experiments sh...

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Identifiers

PMID: 19605477
DOI: 10.1128/JVI.00509-09
PMCID: PMC2748021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19605477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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