The p53 tumour suppressor gene and the tobacco industry: research, debate, and conflict of interest.

doi:10.1016/S0140-6736(05)17871-4

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Article

The p53 tumour suppressor gene and the tobacco industry: research, debate, and conflict of interest.

Lancet (London, England) - 1 Jan 2000

Bitton Asaf, Neuman Mark D, Barnoya Joaquin, Glantz Stanton A

Abstract excerpt

Mutations in the p53 tumour suppressor gene lead to uncontrolled cell division and are found in over 50% of all human tumours, including 60% of lung cancers. Research published in 1996 by Denissenko and colleagues demonstrated patterned in-vitro mutagenic effects on p53 of benzo[a]pyrene, a carcinogen present in tobacco smoke. We investigated the tobacco industry's response to p53 research linking smoking to...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Biomedical Research
Carcinogens
Cells, Cultured
Conflict of Interest
Genes, p53
Humans
Lung Neoplasms
Mutation
Research Personnel
Scientific Misconduct
Smoking
Tobacco Industry

Source

Open in PubMed

Identifiers

PMID: 15705463
DOI: 10.1016/S0140-6736(05)17871-4

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