Article
The p53 tumour suppressor gene and the tobacco industry: research, debate, and conflict of interest.
Lancet (London, England) - 1 Jan 2000
Bitton Asaf, Neuman Mark D, Barnoya Joaquin, Glantz Stanton A
Abstract excerpt
Mutations in the p53 tumour suppressor gene lead to uncontrolled cell division and are found in over 50% of all human tumours, including 60% of lung cancers. Research published in 1996 by Denissenko and colleagues demonstrated patterned in-vitro mutagenic effects on p53 of benzo[a]pyrene, a carcinogen present in tobacco smoke. We investigated the tobacco industry's response to p53 research linking smoking to...
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