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Article

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.

Cancer research - 1 Jul 2008

Datta Jharna, Kutay Huban, Nasser Mohd W, Nuovo Gerard J, Wang Bo, Majumder Sarmila, Liu Chang-Gong, Volinia Stefano, Croce Carlo M, Schmittgen Thomas D, Ghoshal Kalpana, Jacob Samson T

Abstract excerpt

MicroRNAs (miR) are a class of small ( approximately 21 nucleotide) noncoding RNAs that, in general, negatively regulate gene expression. Some miRs harboring CGIs undergo methylation-mediated silencing, a characteristic of many tumor suppressor genes. To identify such miRs in liver cancer, the miRNA expression profile was analyzed in hepatocellular carcinoma (HCC) cell lines treated with 5-azacytidine (DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18593903
DOI: 10.1158/0008-5472.CAN-07-6655
PMCID: PMC2562630

Genes

DNMT1
MET
HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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